Gadd45a Functions as a Promoter or Suppressor of Breast Cancer Dependent on the Oncogenic Stress
نویسندگان
چکیده
منابع مشابه
Gadd45a functions as a promoter or suppressor of breast cancer dependent on the oncogenic stress.
Gadd45a plays a pivotal role as a stress sensor that modulates cellular responses to various stress stimuli including oncogenic stress. We reported that the stress sensor Gadd45a gene functions as a tumor suppressor in Ras-driven breast tumorigenesis via increasing JNK-mediated apoptosis and p38-mediated senescence. In contrast, here, we show that Gadd45a promotes Myc-driven breast cancer by ne...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2010
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-10-2177